ABSTRACT
<p><b>OBJECTIVE</b>To optimize the method of Fructus Auranti extracts preparation.</p><p><b>METHOD</b>The extraction conditions and resin type were examined by using naringin as main indices. The sampling amount, the elution solvent and their flow rates were optimized. The recycling times and recovery capacity of resin were also studied.</p><p><b>RESULT</b>The best extraction could be obtained by adding 10 times amount of NaOH (pH 11) for 3 times, 1 hour each time. The purification conditions were specified as follows: using D101 macroporous resin, the sampling ratio of resin weight to raw material was 1:0.8 with a flow rate of 2 BV x h(-1) and 4 BV 50% aqueous ethanol as elusion solven.</p><p><b>CONCLUSION</b>By using this method, the naringin in the product could reach above 30%. Besides, the optimum method is simple and practical.</p>